S 32212 hydrochloride

Description

S 32212 hydrochloride is an inverse agonist of 5-HT receptors 5-HT2 CINI and 5-HT2 CVSV Kis=6.6, 8.9 nM and an antagonist of 5-HT2A and ?2?-adrenergic receptors Ki=5.8, 5.8 nM . S 32212 hydrochloride can reduce the binding of GTP?S to G?q, and reduce the activity of phospholipase C PLC in HEK293 cells expressing 5-HT2 CINI receptor and CHO cells expressing 5-HT2 CVSV receptor EC50=38 and 18.6 nM, respectively . S 32212 hydrochloride 2.5 mg/kg reduces 5-HT receptor agonist-induced head twitches and penile erections in mice and rats. S 32212 hydrochloride 10, 40 mg/kg reduces immobility time in the forced swim test and marble burying behavior in mice and rats, exerting antidepressant and anxiolytic activities.