(S)-BMS-378806

Description

S -BMS-378806 S -BMS-806 is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. S -BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of S -BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N,N-disubstituted aminoureas and thioureas. S -BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA.