(S)-CPP sodium

Description

S -CPP sodium serves as an inhibitor of the branched-chain ?-ketoacid dehydrogenase complex BCKDC kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, the inhibition of BDK by S -CPP with an IC50 of 6.3 ?M results in the activation of the complex and a notable decrease in plasma levels of leucine/isoleucine and valine in wild-type mice.