GENERAL CATALOGUE
(S)-Crizotinib
HY-100549 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-100549
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Catalog No: HY-100549
CAS No: 1374356-45-2
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
S -Crizotinib is a potent and selective MTH1 mutT homologue inhibitor with an IC50 of 330 nM. S -Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models.
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