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(S)-PFI-2 hydrochloride
GENERAL CATALOGUE

(S)-PFI-2 hydrochloride

HY-110196 · 1 mg

MedChemExpress · Cat: HY-110196

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Catalog No: HY-110196
CAS No: 1627607-88-8
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress

Description

S -PFI-2 hydrochloride is an inhibitor of lysine methyltransferase SETD7 and is approximately 500-fold more active than its enantiomer R -PFI-2. R -PFI-2 is a cofactor-dependent and substrate-competitive inhibitor. R -PFI-2 can occupy the substrate peptide binding groove of SETD7 including the catalytic lysine binding channel and interact with the cofactor The donor methyl group is in direct contact. However, S -PFI-2 was not observed to have the same interaction as R -PFI-2.

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