GENERAL CATALOGUE
(S,R)-GSK321
HY-128888B · 5 mg
MedChemExpress · Cat: HY-128888B
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Catalog No: HY-128888B
CAS No: 1816272-18-0
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
S,R -GSK321 is the S,R -enantiomer of GSK321 HY-18948 . GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia AML and other cancers.
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