(S)-Ro 32-0432

Description

S -Ro 32-0432 is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of S -Ro 32-0432 for PKC?, PKC?I, PKC?II, PKC? and PKC? are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. S -Ro 32-0432 is also a selective G protein-coupled receptor kinase 5 GRK5 inhibitor. S -Ro 32-0432 prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research.