(S)-Sunvozertinib

Description

S -Sunvozertinib S -DZD9008 , the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively . S -Sunvozertinib also inhibits BTK.