GENERAL CATALOGUE
SA09-Cu
HY-150260 · 50 mg
MedChemExpress · Cat: HY-150260
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Catalog No: HY-150260
CAS No: 155641-16-0
Category: Anti-infection
Pack Size: 50 mg
Brand: MedChemExpress
Description
SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn II -thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae CRE in restoring the Meropenem HY-13678 effect, and slows down the development of carbapenem resistance.
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