GENERAL CATALOGUE
SACLAC
HY-158783 · 5 mg
MedChemExpress · Cat: HY-158783
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medchemexpress.com/saclac.htmlCatalog No: HY-158783
CAS No: 2248703-42-4
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase ASAH1; AC inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate S1P and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia AML cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models.
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