GENERAL CATALOGUE
SAH-SOS1A TFA
HY-P2265A · 1 mg
MedChemExpress · Cat: HY-P2265A
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Catalog No: HY-P2265A
CAS No: 2896737-31-6
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS G12D, G12V, G12C, G12S, and Q61H with nanomolar affinity EC50=106-175 nM . SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.
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