Sancycline

Description

Sancycline 6-Demethyl-6-deoxytetracycline acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline HY-A0107 . Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline HY-A0107 prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin.