GENERAL CATALOGUE
SAR-020106
HY-100195 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-100195
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medchemexpress.com/sar-020106.htmlCatalog No: HY-100195
CAS No: 1184843-57-9
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents.