SARS-CoV-2 Mpro-IN-41

Description

SARS-CoV-2 Mpro-IN-41 Compound 7e is an orally active inhibitor of COX-2 and SARS-CoV-2 M pro IC50 values are 9.66 ?M and 13.24 ?M, respectively . SARS-CoV-2 Mpro-IN-41 also has a certain inhibitory activity against COX-1 IC50: 46.11 ?M . SARS-CoV-2 Mpro-IN-41 can significantly inhibit the expression of inflammatory-related cytokines such as TNF-?, IL-6, IL-1? and exert anti-inflammatory effects. SARS-CoV-2 Mpro-IN-41 exerts anti-inflammatory and antiviral effects by selectively inhibiting COX-2 and SARS-CoV-2 M pro. SARS-CoV-2 Mpro-IN-41 can be used for anti-inflammatory and anti-coronavirus research.