GENERAL CATALOGUE
SB-209670
HY-19210 · 1 mg
MedChemExpress · Cat: HY-19210
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Catalog No: HY-19210
CAS No: 157659-79-5
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin ET receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB Ki=0.2 and 18 nM, respectively . SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty.
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