GENERAL CATALOGUE
SB-218078
HY-107407 · 1 mg
MedChemExpress · Cat: HY-107407
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Manufacturer product page
medchemexpress.com/sb-218078.htmlCatalog No: HY-107407
CAS No: 135897-06-2
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 Chk1 inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 IC50 of 250 nM and PKC IC50 of 1000 nM . SB-218078 causes apoptosis by DNA damage and cell cycle arrest.
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