SB 242084 monohydrochloride

Description

SB 242084 monohydrochloride is a selective, competitive and high-affinity pKi=9.0 5-HT2C receptor antagonist crosses the blood-brain barrier . SB 242084 monohydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area VTA of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 monohydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.