GENERAL CATALOGUE
SB-273005
HY-19307 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-19307
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medchemexpress.com/sb-273005.htmlCatalog No: HY-19307
CAS No: 205678-31-5
Category: Cytoskeleton
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
SB-273005 is an orally active non-peptide ?v?3 integrin antagonist with Ki values of 1.2 nM and 0.3 nM for ?v?3 and ?v?5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. .
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