GENERAL CATALOGUE
SB-612111 hydrochloride
HY-18618A · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-18618A
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Manufacturer product page
medchemexpress.com/sb-612111-hydrochloride-1.htmlCatalog No: HY-18618A
Category: GPCR G Protein
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor ORL-1 antagonist with a high affinity for hORL-1 Ki=0.33 nM . SB-612111 hydrochloride exhibits selectivity for ?-,??- and??-receptors with Ki values of?57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin HY-P0183 in an acute pain model.