SB-T-1214

Description

SB-T-1214 SBT is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes Oct4, Sox2, and c-Myc and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133+/CD44+ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers.