GENERAL CATALOGUE
SC144
HY-15614 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-15614
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Catalog No: HY-15614
CAS No: 895158-95-9
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SC144 is a first-in-class, orally active gp130 IL6-beta inhibitor. SC144 binds gp130, induces gp130 phosphorylation S782 and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells.
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