GENERAL CATALOGUE
SC428
HY-164373 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-164373
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Catalog No: HY-164373
CAS No: 1898232-70-6
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SC428 is an androgen receptor AR inhibitor that targets the N-terminal domain. SC428 potently decrease the transactivation of AR -V7, AR v567es, as well as full-length AR AR-FL and its LBD mutants, substantially. SC428 inhibits androgen-stimulated AR -FL nuclear translocation, chromatin binding, and AR -regulated gene transcription. SC428 inhibits the proliferation of tumor cells in vitro. SC428 inhibits tumor cell growth by inducing apoptosis in mice transplanted with 22RV1.
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