GENERAL CATALOGUE
SD-91
HY-150251 · 1 mg
MedChemExpress · Cat: HY-150251
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medchemexpress.com/stat3-degrader-2.html
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Catalog No: HY-150251
CAS No: 2497583-03-4
Category: JAK STAT Signaling
Pack Size: 1 mg
Brand: MedChemExpress
Description
SD-91 STAT3 degrader-2 , a product of the hydrolysis of SD-36 HY-129602 , is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma Pink: ligand for target protein HY-150895 ; Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506 .
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