SDH-IN-25

Description

SDH-IN-25 is a succinate dehydrogenase SDH inhibitor IC50 = 4.82 mg/L . SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad HY-135549 through binding to SDH amino acid residues TRP173, TYR58, and ARG43 . SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species ROS , and affect mitochondrial membrane potential MMP in mycelia. SDH-IN-25 can be studied in research for agricultural disease control.