GENERAL CATALOGUE
SEC inhibitor KL-2
HY-123972 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-123972
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medchemexpress.com/sec-inhibitor-kl-2.htmlCatalog No: HY-123972
CAS No: 900308-51-2
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SEC inhibitor KL-2 KL-2 , a peptidomimetic lead compound, is a potent, selective super elongation complex SEC inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 ?M.
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