?-Secretase inhibitor 11

Name: ?-Secretase inhibitor 11
Brand: MedChemExpress

HY-124832 · Free Sample (0.1 - 0.2 mg)

MedChemExpress · Cat: HY-124832

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medchemexpress.com/%CE%B4-secretase-inhibitor-11.html

Catalog No: HY-124832

CAS No: 842964-18-5

Category: Apoptosis

Pack Size: Free Sample (0.1 - 0.2 mg)

Brand: MedChemExpress

Description

?-Secretase inhibitor 11 compound 11 is an orally active, potent, BBB-penetrated, non-toxic, selective and specific ?-secretase inhibitor, with an IC50 of 0.7 ?M. ?-Secretase inhibitor 11 interacts with both the active site and allosteric site of ?-secretase. ?-Secretase inhibitor 11 attenuates tau and APP amyloid precursor protein cleavage. ?-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. ?-Secretase inhibitor 11 can be used for Alzheimers disease research.