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Serpin B9-IN-1
GENERAL CATALOGUE

Serpin B9-IN-1

HY-33299 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-33299

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Catalog No: HY-33299
CAS No: 154235-77-5
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

Serpin B9-IN-1 BTCA is an inhibitor that specifically targets Serpin B9 SB9 ; SB9 is a natural inhibitor of granzyme B GrB , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery CA mouse model LCBM .

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