

HY-33299 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-33299
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medchemexpress.com/serpin-b9-in-1.htmlDescription
Serpin B9-IN-1 BTCA is an inhibitor that specifically targets Serpin B9 SB9 ; SB9 is a natural inhibitor of granzyme B GrB , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery CA mouse model LCBM .



