GENERAL CATALOGUE
Setidegrasib
HY-148273 · 1 mg
MedChemExpress · Cat: HY-148273
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Catalog No: HY-148273
CAS No: 2821793-99-9
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
Setidegrasib KRAS G12D inhibitor 17, ASP3082 is a PROTAC KRAS degrader DC50: 37 nM . Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib suppresses p-ERK, p-AKT, p-S6 levels in AsPC-1 cells. Setidegrasib exhibits anti-tumor activity in various cancer xenograft models in mice. Setidegrasib can be used for the study of KRAS G12D -mutated solid tumors. Blue: VHL ligase ligand HY-168699 ; Black: linker HY-168698 ; Pink: G12D ligand HY-168700 .
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