GENERAL CATALOGUE
SGLT2-IN-2
HY-174400 · 5 mg
MedChemExpress · Cat: HY-174400
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medchemexpress.com/sglt2-in-2.htmlCatalog No: HY-174400
Category: Autophagy
Pack Size: 5 mg
Brand: MedChemExpress
Description
SGLT2-IN-2 Compound E9 is an inhibitor of SGLT2. SGLT2-IN-2 significantly enhances the inhibition of SGLT2, NHE1, and SOD enzyme activity. SGLT2-IN-2 has protective effect on the glucose-free DMEM-induced injured cardiomyocytes. SGLT2-IN-2 significantly improves cardiac function in TAC-induced HF mice and inhibits cardiomyocyte hypertrophy as well as collagen deposition. SGLT2-IN-2 can ameliorate myocardial tissue damage and enhance mitochondrial autophagy in injured cardiomyocytes, thereby increasing survival rates in HF mice.
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