Sgo2 Rabbit Polyclonal Antibody

Description

EnkiLife offers the Sgo2 Rabbit Polyclonal Antibody. This antibody reacts with Human,Rat,Mouse species and is suitable for IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: SGOL2; Shugoshin-like 2; Shugoshin-2; Sgo2; Tripin. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000 Background: function:During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. sequence caution:Contaminating sequence. Potential poly-A sequence. similarity:Belongs to the shugoshin family. subcellular location:In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. subunit:Directly interacts with PPP2CA.