GENERAL CATALOGUE
SHP2/CDK4-IN-1
HY-150609 · 50 mg
MedChemExpress · Cat: HY-150609
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Manufacturer product page
medchemexpress.com/shp2-cdk4-in-1.htmlCatalog No: HY-150609
CAS No: 2924036-87-1
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
SHP2/CDK4-IN-1 compound 10 is an orally active and potent SHP2 and CDK4 dual inhibitor, with IC50 values of 4.3 and 18.2 nM, respectively. SHP2/CDK4-IN-1 effectively induces G0/G1 arrest to prevent the proliferation of TNBC cell lines. SHP2/CDK4-IN-1 shows significant antitumor efficacy in the EMT6 syngeneic mouse model. SHP2/CDK4-IN-1 can be used for triple-negative breast cancer TNBC research.
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