SHP2-IN-33

Description

SHP2-IN-33 Compound D13 is an allosteric inhibitor of SHP2 with an IC50 of 1.2 ?M. In cellular studies, SHP2-IN-33 demonstrates antiproliferative activity with an IC50 of 38 ?M against Huh7 cells by arresting the G0/G1 cell cycle, promoting apoptosis Apoptosis , and suppressing the MAPK signaling pathway. In an in vivo Huh7 xenograft mouse model, SHP2-IN-33 exhibits significant antitumor activity and favorable pharmacokinetics, including 54 % oral bioavailability and a half-life of 10.57 hours. SHP2-IN-33 is a promising compound for studying tumor diseases associated with SHP2.