GENERAL CATALOGUE
Sibiriline
HY-120600 · 50 mg
MedChemExpress · Cat: HY-120600
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medchemexpress.com/sibiriline.htmlCatalog No: HY-120600
CAS No: 1346526-26-8
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis..
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