Sigma-1 receptor antagonist 5

Description

Sigma-1 receptor antagonist 5 compound 12 ?a 4-pyridylpiperidine derivative with analgesic activity?is an antagonist of sigma receptor Ki=4.5 nM ?1R ?10 nM ?2R and histamine H3 hH3R?Ki=7.7 nM?IC50=215 nM . Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models.