SIK1 Rabbit Polyclonal Antibody

Description

EnkiLife offers the SIK1 Rabbit Polyclonal Antibody. This antibody reacts with Human,Rat species and is suitable for WB,IHC application. Alternative Names of Immunogen: SIK1; SIK; SNF1LK; Serine/threonine-protein kinase SIK1; Salt-inducible kinase 1; SIK-1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:50-1:300 Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. similarity:Contains 1 protein kinase domain. similarity:Contains 1 UBA domain. subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ. subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.