SIKs-IN-1

Description

SIKs-IN-1 compound 8h , a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases SIKs inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model.