Silybin B

Description

Silybin B Silibinin B is an orally active amyloid-? aggregation inhibitor and ATR pathway activator, that can cross the blood-brain barrier. Silybin B inhibits A? fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin HY-17394 -induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimers disease and Cisplatin chemotherapy-related neurotoxicity.