GENERAL CATALOGUE
Simeprevir
HY-10241 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-10241
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Catalog No: HY-10241
CAS No: 923604-59-5
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Simeprevir TMC435; TMC435350 is an oral, potent and highly specific hepatitis C virus HCV NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease Mpro and the RNA-dependent RNA polymerase RdRp of SARS-CoV-2, and also modulates host immune responses.
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