GENERAL CATALOGUE
Simmiparib
HY-115552 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-115552
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medchemexpress.com/simmiparib.htmlCatalog No: HY-115552
CAS No: 1551355-46-4
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Simmiparib is a highly potent and orally active PARP1 and PARP2 inhibitor with IC50 values of 1.75 nM and 0.22 nM, respectively. Simmiparib has more potent PARP1/2 inhibition than its parent Olaparib HY-10162 . Simmiparib induces DNA double-strand breaks DSB accumulation and G2/M arrest in homologous recombination repair HR -deficient cells, thereby inducing apoptosis. Simmiparib exhibits remarkable anticancer activities in cells and nude mice bearing xenografts.
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