GENERAL CATALOGUE
Sipeimine
HY-N0696 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-N0696
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Catalog No: HY-N0696
CAS No: 61825-98-7
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Sipeimine Imperialine is an inhibitor targeting the PI3K/AKT/NF-?B pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-?B nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases.
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