GENERAL CATALOGUE
Siramesine hydrochloride
HY-14221A · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-14221A
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medchemexpress.com/Siramesine-hydrochloride.htmlCatalog No: HY-14221A
CAS No: 224177-60-0
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Siramesine Lu 28-179 hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors IC50=0.12 nM and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors IC50=17 nM . Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.
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