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SIRT7 Stable Knockdown HeLa Cell Line
GENERAL CATALOGUE

SIRT7 Stable Knockdown HeLa Cell Line

T6164 · 1 x 106 cells / 1.0 mL

abm good · Cat: T6164

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Catalog No: T6164
Category: Cellular Materials
Pack Size: 1 x 106 cells / 1.0 mL
Brand: abm good

Description

SIRT7 Stable Knockdown HeLa Cell Line was generated by lentiviral driven expression of shRNAs. Lack of Sirt7 is associated with reduced recruitment of DNMT1 and Sirt1 at rRNA genes leading to hyperacetylation of histones, reduced DNA methylation, fragmentation of the nucleolar structure and loss of rDNA repeats leading to an increased spontaneous immortalization of primary mouse embryonic fibroblasts.

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