Sitagliptin phosphate (Standard)

Description

Sitagliptin MK-0431 phosphate Standard is the analytical standard of Sitagliptin phosphate HY-13749A . This product is intended for research and analytical applications. Sitagliptin phosphate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin phosphate blocks the degradation of glucagon-like peptide-1 GLP-1 and glucose-dependent insulinotropic peptide GIP by competing inhibition mechanism K? = 1 nM , thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate can be used for the study of 1-type and 2-type diabetes.