GENERAL CATALOGUE
SJ10542
HY-145696 · 1 mg
MedChemExpress · Cat: HY-145696
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medchemexpress.com/sj10542.htmlCatalog No: HY-145696
CAS No: 2789678-92-6
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
SJ10542 is a potent and selective JAK2/3 PROTAC degrader. In PDX cells lSJBALL020589, SJ10542 has DC50 values of 14 and 11 nM for JAK2 and JAK3, respectively. SJ10542 exhibits antitumor activity and can be used for the research of hematological malignancies and autoimmune diseases. Pink: Target protein ligand HY-47073 ; Black: Linker HY-W251248 ; Blue: E3 ligase ligand HY-W890189 ; E3 ligase ligand+Linker HY-176425