GENERAL CATALOGUE
SJ11646
HY-175281 · 50 mg
MedChemExpress · Cat: HY-175281
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medchemexpress.com/sj11646.htmlCatalog No: HY-175281
CAS No: 2933135-82-9
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
SJ11646 is a Dasatinib HY-10181 -based LCK PROTAC degrader with a DC50 of 0.00838 pM. SJ11646 has potent cytotoxicity against LCK-activated T-cell acute lymphoblastic leukemia T-ALL cells and primary leukemia samples with drastically prolonged suppression of LCK signaling, and induces T-ALL apoptosis. SJ11646 binds to 51 human kinases with a high affinity particularly ABL1, KIT, and DDR1 . SJ11646 has superior antileukemic efficacy in T-ALL mice model. . Pink: LCK ligand HY-107447 ; Blue: CRBN ligase ligand HY-163169 ; Black: linker HY-76667
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