GENERAL CATALOGUE
SJ46421
HY-168634 · 50 mg
MedChemExpress · Cat: HY-168634
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Manufacturer product page
medchemexpress.com/sj46421.htmlCatalog No: HY-168634
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
SJ46421 is a + -JQ-1 HY-13030 based KLHDC2-BRD3 PROTAC protein degrader. SJ46421 induces cooperative ternary complexes with KLHDC2 and BRD3BD2, with an IC50 of 7.8?nM. SJ46421 selectively inhibits KLHDC2 substrate ubiquitylation. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4. SJ46421 possesses poor cell permeability. Pink: ligand for target protein HY-13030 ; Black: linker HY-20797 ; Blue: E3 ligase ligand HY-168536 .
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