GENERAL CATALOGUE
SJF-0628
HY-136420 · 1 mg
MedChemExpress · Cat: HY-136420
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medchemexpress.com/sjf-0628.htmlCatalog No: HY-136420
CAS No: 2413035-41-1
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
SJF-0628 is a RAF PROTAC degrader. SJF-0628 induces targeted degradation of BRAF in various cancer cell lines colorectal cancer cell lines Colo-205, LS-411N, HT-29, RKO and triple-negative breast cancer cell line DU-4475 . SJF-0628 decreases pMEK and pErk levels in DU-4475 cells. SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of colorectal cancer and triple-negative breast cancer. Pink: RAF ligand HY-12057 , Blue: VHL Ligand HY-125845 , Black: Linker HY-B0912 .