GENERAL CATALOGUE
SJF-1528
HY-131864 · 1 mg
MedChemExpress · Cat: HY-131864
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medchemexpress.com/sjf-1528.htmlCatalog No: HY-131864
CAS No: 2230821-38-0
Category: JAK STAT Signaling
Pack Size: 1 mg
Brand: MedChemExpress
Description
SJF-1528 PROTAC 1 is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 also degrades HER2. SJF-1528 promotes ubiquitination and degradation of EGFR and can be used in breast cancer research Pink: ligand for target protein HY-159047 ; Black: linker Tos-PEG2-CH2-Boc HY-130532 ; Blue: ligand for E3 ligase S,R,S -AHPC HY-125845 .
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