

HY-171767 · 1 mg
MedChemExpress · Cat: HY-171767
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medchemexpress.com/sk2188.html
Description
SK2188 is a highly efficient and selective PROTAC degrader targeting AURKA DC50 = 3.9 nM . SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma Pink: AURKA ligand: MK-5108 HY-13252 ; Blue: Thalidomide HY-14658 ; Black: Linker: Amino-PEG4-alcohol HY-W008005 .







