GENERAL CATALOGUE
SKI-178
HY-12892 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-12892
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Catalog No: HY-12892
CAS No: 1259484-97-3
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SKI-178 is a potent sphingosine kinase-1 SphK1 and SphK2 inhibitor. SKI-178 is cytotoxic at IC50 concentrations ranging from 1.8 to 0.1 ?M in both agent sensitive and multi-agent resistant cancer cell lines i.e., MTR3, NCI-ADR and HL60/VCR cells . SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines.
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